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Related Experiment Video

Updated: Oct 20, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Lentigo Maligna.

Jacob D Franke¹, Katlyn M Woolford¹, Michael W Neumeister²

¹Southern Illinois University, School of Medicine, 747 N. Rutledge Street, Springfield, IL 62702, USA.

Clinics in Plastic Surgery

|September 10, 2021

Summary

This summary is machine-generated.

Lentigo maligna (LM) is a type of melanoma in situ affecting sun-exposed skin, primarily in older adults. It is confined to the epidermis but can progress to lentigo maligna melanoma if it invades the dermis.

Keywords:

Lentigo Maligna Lentigo Maligna Melanoma Melanoma in situ

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Published on: June 7, 2019

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Lentigo maligna (LM) is a melanocytic neoplasm commonly found on chronically sun-exposed skin, particularly the head and neck.
It predominantly affects the elderly population and has historical names such as "senile freckle" and "Hutchinson melanotic freckle."
LM is histopathologically defined as melanoma in situ, meaning it is confined to the epidermis.

Purpose of the Study:

To provide a comprehensive overview of Lentigo Maligna.
To differentiate between Lentigo Maligna and Lentigo Maligna Melanoma.
To highlight the clinical and pathological characteristics of this specific melanoma subtype.

Main Methods:

Review of existing literature and case studies.
Histopathological analysis of skin lesions.
Clinical observation of patient demographics and lesion presentation.

Main Results:

Lentigo maligna is characterized by its slow growth and predilection for sun-damaged skin.
The key diagnostic feature is the confinement of atypical melanocytes to the epidermis.
Invasion into the dermis signifies progression to lentigo maligna melanoma, a more advanced stage.

Conclusions:

Lentigo maligna represents an early stage of melanoma, emphasizing the importance of early detection and diagnosis.
Distinguishing LM from invasive lentigo maligna melanoma is crucial for appropriate treatment and prognosis.
Continued research into the pathogenesis and management of LM is warranted.