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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Association of Arterial Stiffness With Chronic Kidney Disease Progression and Mortality

Julija G Voicehovska1, Eva Bormane2, Anda Grigane2

  • 1Department of Internal Diseases, Riga Stradins University, Riga, Latvia; Department of Kidney Diseases and Renal Replacement Therapy, Riga East Clinical University Hospital, Riga, Latvia.

Heart, Lung & Circulation
|September 10, 2021
PubMed

Insights

Arterial stiffness (AS) is linked to chronic kidney disease (CKD) progression. This review explores how measuring AS aids in CKD assessment and management, highlighting its role in cardiovascular disease risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a significant public health issue, with cardiovascular disease (CVD) being the leading cause of mortality in patients.
  • Patients with end-stage renal disease face a 10-30 times higher age-adjusted CVD mortality rate compared to the general population.
  • Declining renal function accelerates cardiac pathology, and the interplay between CVD and CKD is crucial in understanding arterial stiffness (AS) and estimated glomerular filtration rate (eGFR).

Purpose of the Study:

  • To review the theoretical background, current status, and future potential of techniques used to measure arterial stiffness (AS).
  • To examine the role of AS measurement in the assessment and management of chronic kidney disease (CKD).
  • To explore the controversial relationship between AS and kidney function decline.

Main Methods:

  • Review of existing literature on arterial stiffness (AS) and chronic kidney disease (CKD).
  • Analysis of studies investigating markers of AS (e.g., pulse pressure, central and peripheral pressure) in relation to CKD development.
  • Consideration of theoretical frameworks and current techniques for AS measurement.

Main Results:

  • Several studies indicate that markers of AS are associated with the development and progression of CKD.
  • Comorbidities in high-risk populations may contribute to both AS and kidney function decline over time.
  • The precise causal relationship between AS and renal dysfunction (whether AS causes CKD, CKD causes AS, or it's reciprocal) remains debated.

Conclusions:

  • Arterial stiffness is a significant factor in chronic kidney disease (CKD) patients, contributing to cardiovascular mortality.
  • Measuring AS offers potential for improved CKD assessment and management strategies.
  • Further research is needed to elucidate the complex, potentially reciprocal relationship between arterial stiffness and kidney function.

Keywords:
Arterial stiffnessCV risk predictionChronic kidney diseaseMortalityPrognosisVascular ageing

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