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Updated: Oct 20, 2025

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Thyroid Dysfunction and Sleep Disorders.

Max E Green1, Victor Bernet2,3, Joseph Cheung4

  • 1Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Jacksonville, FL, United States.

Frontiers in Endocrinology
|September 10, 2021
PubMed
Summary
This summary is machine-generated.

Thyroid disorders like hyperthyroidism and hypothyroidism are linked to common sleep issues including insomnia and sleep apnea. Early identification and management of thyroid problems are crucial for patients with sleep disorders.

Keywords:
hyperthyroidismhypothyroidisminsomniaobstructiverestless legs syndromesleepsleep apneasleep initiation and maintenance disorders

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Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Thyroid disorders and sleep disorders are prevalent in the general population.
  • The clinical associations between these two conditions are not well understood.
  • Both conditions affect diverse demographics across all ages and sexes.

Purpose of the Study:

  • To review existing literature on the associations between thyroid disease and sleep disorders.
  • To identify clinical overlaps between specific thyroid dysfunctions and sleep conditions.
  • To emphasize the importance of managing thyroid dysfunction in patients with sleep disorders.

Main Methods:

  • Literature review of studies assessing thyroid disease and sleep disorder associations.
  • Analysis of clinical overlap between hyperthyroidism/hypothyroidism and common sleep disorders.
  • Synthesis of findings to highlight clinical significance and research gaps.

Main Results:

  • Thyroid disorders, specifically hyperthyroidism and hypothyroidism, show significant clinical overlap with sleep disorders.
  • Commonly associated sleep conditions include insomnia, restless legs syndrome, and obstructive sleep apnea.
  • The review confirms a notable association between thyroid dysfunction and various sleep disturbances.

Conclusions:

  • Identifying and managing thyroid dysfunction is essential for patients presenting with common sleep disorders.
  • Further research is necessary to elucidate the precise mechanisms by which thyroid dysfunction impacts sleep physiology.
  • Clinical practice should consider screening for thyroid issues in patients with persistent sleep complaints.