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Evaluation and Management of Early Onset Genetic Obesity in Childhood

Sonali Malhotra1, Ramya Sivasubramanian2, Gitanjali Srivastava3

  • 1Department of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, United States.

Journal of Pediatric Genetics
|September 10, 2021
PubMed

Insights

Severe obesity in children and adolescents is a growing concern, with genetic factors playing a significant role. Early identification and advanced genetic testing are crucial for developing targeted treatments for monogenic and syndromic obesity.

Area of Science:

  • Pediatric Endocrinology
  • Medical Genetics
  • Obesity Research

Background:

  • Childhood obesity affects 1 in 5 US youth, with severe obesity in nearly 6%.
  • Over 7% of severe obesity cases are linked to genetic disorders.

Purpose of the Study:

  • To review monogenic and syndromic obesity in children and adolescents.
  • To discuss etiology, clinical presentation, early identification, and management limitations.

Main Methods:

  • Literature review focusing on genetic obesity.
  • Analysis of advanced genetic testing methods (microarray, whole genome sequencing).

Main Results:

  • Monogenic and syndromic obesity present a wide clinical spectrum.
  • Genetic testing is essential for identifying specific mutations.

Conclusions:

  • Early identification of genetic obesity is critical.
  • Targeted treatments, including personalized care, investigational drugs, and surgery, are needed for severe pediatric obesity.

Keywords:
genetic obesityhyperphagiainfantile obesitypediatric obesitypediatric weight managementweight-for-length percentile

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