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CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis

Haifeng Jin1, Zheng Wu2, Bibo Tan3

  • 1Department of Gastroenterology, The 980th Hospital of the PLA Joint Logistics Support Force (Primary Bethune International Peace Hospital of PLA), Shijiazhuang, China.

Frontiers in Cell and Developmental Biology
|September 10, 2021
PubMed

Insights

Circular RNAs (circRNAs) like circITGA7 are involved in gastric cancer (GC) progression. This study reveals circITGA7 acts as a tumor suppressor by regulating the circITGA7/miR-1471/MTDH axis in GC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Circular RNAs (circRNAs) are increasingly implicated in gastric cancer (GC) pathogenesis.
  • The precise molecular mechanisms underlying circRNA involvement in GC cell proliferation, invasion, and migration remain largely undefined.

Purpose of the Study:

  • To investigate the role of differentially expressed circRNAs in gastric cancer.
  • To elucidate the molecular mechanism of circITGA7 in GC progression.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) database for differentially expressed circRNAs in GC.
  • Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis.
  • In vitro experiments involving circITGA7 silencing and overexpression, and investigation of the miR-1471/metadherin (MTDH) axis.

Main Results:

  • circITGA7 was found to be downregulated in GC tissues.
  • Silencing circITGA7 enhanced GC cell proliferation and metastasis; overexpression inhibited these processes.
  • circITGA7 functions as a sponge for miR-1471, which targets metadherin (MTDH).
  • The tumor suppressive effect of circITGA7 is mediated through the regulation of the miR-1471/MTDH axis.

Conclusions:

  • The circITGA7/miR-1471/MTDH signaling pathway plays a significant role in gastric cancer progression.
  • circITGA7 represents a potential therapeutic target and biomarker for GC.
Keywords:
CircITGA7MTDHThe Cancer Genome Atlasgastric cancermiR-1471

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