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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Related Experiment Video

Updated: Oct 20, 2025

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
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Ischemic tolerance - blessing or curse.

J Burda1, R Burda

  • 1Institute of Neurobiology of Biomedical Research Center, Slovak Academy of Sciences, Košice, Slovak Republic. Faculty of Medicine, Clinic of Trauma Surgery, P. J. Šafárik University, Košice, Slovak Republic. rastislav.burda@upjs.sk.

Physiological Research
|September 10, 2021
PubMed
Summary
This summary is machine-generated.

This study explores using activated blood plasma to induce ischemic tolerance, potentially offering immediate protection against tissue damage upon hospital admission. This method may also enhance cancer treatment effectiveness.

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Area of Science:

  • Cardiovascular Science
  • Translational Medicine
  • Oncology

Background:

  • Ischemic tolerance is a protective phenomenon against ischemia-reperfusion injury.
  • Understanding its mechanisms is crucial for clinical application.
  • Previous research has explored various aspects of ischemic tolerance.

Purpose of the Study:

  • To review existing research on ischemic tolerance.
  • To present experimental findings on preparing and transferring ischemic tolerance via activated blood plasma.
  • To explore the concept and potential application of anticonditioning in cancer treatment.

Main Methods:

  • Review of laboratory research on ischemic tolerance.
  • Experimental studies focusing on donor-body preparation and activated plasma transfer.
  • Investigation into anticonditioning strategies for cancer therapy.

Main Results:

  • Activated blood plasma can be prepared from a donor and administered to patients.
  • This plasma may provide immediate protective effects against ischemic events.
  • Anticonditioning presents a potential strategy to improve cancer treatment efficacy.

Conclusions:

  • Activated plasma holds promise for immediate clinical application in managing ischemic events.
  • Anticonditioning could be a valuable tool in oncologic patient care.
  • The cross-tolerance induced by activated plasma suggests broad therapeutic potential for various pathological conditions.