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Use of Statins as Lipid Lowering Agent in Hypercholesterolemia in a Tertiary Care Hospital: A Descriptive

Aashish Kumar Bhattarai1, Anna Acharya1, Prabin Kumar Karki2

  • 1Department of Pharmacology, Kathmandu Medical College, Duwakot, Bhaktapur, Nepal.

JNMA; Journal of the Nepal Medical Association
|September 10, 2021
PubMed

Insights

Doctors most prefer statins for dyslipidemia treatment, with atorvastatin being the most popular choice. Myopathy was the most frequently reported side effect among statin users.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Dyslipidemia, linked to atherosclerosis and obesity, increases cardiovascular disease risk.
  • Statins, HMG-CoA reductase inhibitors, are widely prescribed to manage hypercholesterolemia and optimize lipoprotein profiles.
  • Clinical outcomes guide statin selection for effective dyslipidemia management.

Purpose of the Study:

  • To identify the most preferred statin type for dyslipidemia treatment among physicians.
  • To determine physician preference for fixed-dose statin combinations.
  • To assess statin prescription patterns in a tertiary care hospital setting.

Main Methods:

  • A descriptive cross-sectional study was conducted.
  • Data collected from practicing doctors at Kathmandu Medical College (July-August 2020).
  • A semi-structured questionnaire and convenient sampling were utilized for data collection.

Main Results:

  • Statins were the most preferred drug class for dyslipidemia, scoring 4.25.
  • Atorvastatin (4.48) was the most popular statin, followed by rosuvastatin (2.9) and simvastatin (2.1).
  • Myopathy was identified as the most common side effect associated with statin use.

Conclusions:

  • Statins are the primary choice for treating dyslipidemia.
  • Despite similar efficacy, atorvastatin is the most frequently prescribed statin.
  • Physician preference and reported side effects like myopathy influence statin selection.
Abstract

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