Cannabis use disorder among atrial fibrillation admissions, 2008-2018

Fouad Chouairi1, P Elliott Miller2, Avirup Guha3

  • 1Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Insights

Cannabis use disorder (CUD) is increasingly common in atrial fibrillation (AF) hospitalizations, especially among younger and underserved populations. This trend highlights the need for further research into CUD

Area of Science:

  • Cardiology
  • Public Health
  • Addiction Medicine

Background:

  • Cannabis use disorder (CUD) prevalence is rising amid changing legal landscapes.
  • Limited data exists on the association between CUD and inpatient atrial fibrillation (AF) hospitalizations.

Purpose of the Study:

  • To investigate the prevalence and characteristics of AF hospitalizations with a codiagnosis of CUD.
  • To analyze demographic, socioeconomic, and comorbidity differences between AF patients with and without CUD.

Main Methods:

  • Utilized the National Inpatient Sample (NIS) database.
  • Identified AF hospitalizations with and without CUD using ICD diagnosis codes.
  • Compared patient demographics, socioeconomic factors, comorbidities, and outcomes.

Main Results:

  • Between 2008-2018, 0.6% of 5.1 million AF admissions had a CUD codiagnosis.
  • The proportion of AF admissions with CUD increased from 0.3% to 1.0% (p < .001).
  • CUD patients were younger (53 vs. 72 years), more likely Black (26.6% vs. 8.0%), and from lower income quartiles (40.5% vs. 26.2%).

Conclusions:

  • CUD is a growing concern in AF hospitalizations, particularly affecting younger and underserved demographics.
  • Findings underscore the need to understand CUD's impact on AF patient populations.
  • Evolving cannabis legislation necessitates further research into CUD and AF comorbidities.
Abstract

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
240
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
204
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.6K
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
419
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
27
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
814