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Perturbation-specific responses by two neural circuits generating similar activity patterns.

Daniel J Powell1, Eve Marder1, Michael P Nusbaum2

  • 1Volen Center for Complex Systems and Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.

Current Biology : CB
|September 10, 2021
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Summary

Neuronal circuits producing similar outputs can respond differently to perturbations. Even when activating the same ion current, distinct circuits showed varied responses to hormones but similar responses to sensory neurons.

Keywords:
Cancer borealis pyrokinincentral pattern generatorcircuit flexibilitycrustacean cardioactive peptidedegenerate circuitsdynamic clampgastric mill rhythmgastro-pyloric receptor neuronsneuromodulationstomatogastric ganglion

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal circuits with variable parameters can generate similar activity patterns.
  • Distinct circuits can produce similar outputs through different mechanisms.
  • Understanding circuit responses to perturbations is crucial in neuroscience.

Purpose of the Study:

  • To investigate whether distinct gastric mill circuits in the crustacean stomatogastric ganglion (STG) respond comparably to perturbations.
  • To compare the effects of hormonal (CCAP) and sensory (GPR neuron) influences on two distinct gastric mill circuits.

Main Methods:

  • Utilized two distinct gastric mill circuits in the STG, one driven by modulatory commissural neuron 1 (MCN1) and the other by Cancer borealis pyrokinin (CabPK) peptide.
  • Challenged these circuits with persisting (hormonal: CCAP) and acute (sensory: GPR neuron) metabotropic influences.
  • Analyzed the resulting circuit activity patterns and compared responses between the two circuits.

Main Results:

  • Hormonal CCAP application unexpectedly separated the rhythms of the two circuits, despite activating the same ionic current in the same neuron.
  • Sensory GPR neuron stimulation evoked comparable responses in both circuits, despite acting through different synapses.
  • These findings reveal differential circuit responses to perturbations based on underlying circuit structure and perturbation type.

Conclusions:

  • The study highlights that distinct neuronal circuits, even those producing similar outputs, may not respond comparably to equivalent perturbations.
  • Caution is needed when inferring circuit responses to perturbations if the underlying physiological circuit is not well-defined.
  • Results emphasize the importance of circuit-specific mechanisms in determining functional outcomes.