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Updated: Oct 20, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression
Fabiola Lilí Sarmiento-Salinas1, Andrea Perez-Gonzalez1, Adilene Acosta-Casique1
1Centro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Atlixco, Puebla, Mexico; Posgrado en Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Abstract:
Cancer is one of the major causes of death in the world and its global burden is expected to continue increasing. In several types of cancers, reactive oxygen species (ROS) have been extensively linked to carcinogenesis and cancer progression. However, studies have reported conflicting evidence regarding the role of ROS in cancer, mostly dependent on the cancer type or the step of the tumorigenic process. We review recent studies describing diverse aspects of the interplay of ROS with cancer in the different stages of cancer progression, with a special focus on their role in carcinogenesis, their importance for cancer cell signaling and their relationship to the most prevalent cancer risk factors.
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