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[Human immunodeficiency virus (HIV), thrombopenia and pregnancy]
J Y Gillet1, P Constantopoulos, E Rives
1Service de Gynécologie-Obstétrique, Hôpital Saint-Roch, Nice.
Summary
Human immunodeficiency virus (HIV) can cause thrombocytopenia, a low platelet count, in pregnant women. Intravenous immunoglobulin therapy showed effectiveness in managing this condition in two of three reported cases.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Hematology
Context:
- Thrombocytopenia is a potential complication during pregnancy.
- Human Immunodeficiency Virus (HIV) infection is increasingly recognized in pregnant populations.
- Differentiating HIV-associated thrombocytopenia from other causes is crucial for appropriate management.
Purpose:
- To describe three cases of thrombocytopenia in pregnant women with HIV infection.
- To investigate the efficacy of intravenous immunoglobulin (IVIG) in treating HIV-associated thrombocytopenia during pregnancy.
- To assess the impact on maternal and neonatal outcomes.
Summary:
- Three pregnant women with HIV presented with thrombocytopenia, confirmed to be HIV-associated after excluding other causes.
- Intravenous immunoglobulin (IVIG) treatment was administered, proving effective in two of the three cases.
- Outcomes varied, including uncomplicated recovery, post-delivery hemorrhage, and one maternal death; neonates did not present with thrombocytopenia but showed antibodies, with one developing an AIDS-like syndrome.
Impact:
- Highlights the occurrence of HIV-associated thrombocytopenia in pregnancy, accounting for 8% of complications in the study cohort.
- Demonstrates the potential efficacy of IVIG as a treatment modality for this condition.
- Underscores the importance of long-term follow-up for both mothers and infants affected by HIV during pregnancy.