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Preparation of Acute Human Hippocampal Slices for Electrophysiological Recordings

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Involvement of Incomplete Hippocampal Inversion in Intractable Epilepsy: Evidence from Neuropsychological Studies.

R M Bhoopathy¹, B Arthy¹, S S Vignesh¹

¹Institute of Neurology, Madras Medical College, Chennai, Tamil Nadu, India.

Neurology India

|September 11, 2021

Summary

This summary is machine-generated.

Intractable epilepsy patients experience high rates of anxiety and depression. Incomplete hippocampal inversion (IHI) is particularly linked to anxiety when depression is also present.

Keywords:

Anxiety depression epilepsy incomplete hippocampal inversion malformations of cortical development

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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

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Published on: May 15, 2018

Area of Science:

Neurology
Neuropsychiatry
Medical Imaging

Background:

Intractable epilepsy is associated with increased anxiety and depression.
Factors like seizure characteristics, brain abnormalities, and polytherapy contribute to this comorbidity.

Purpose of the Study:

To compare anxiety and depression levels in intractable epilepsy patients with and without structural brain abnormalities.
Specifically investigated malformations of cortical development (MCD) and incomplete hippocampal inversion (IHI).

Main Methods:

Compared four groups: controls, epilepsy without abnormalities, epilepsy with MCD, and epilepsy with isolated IHI.
Utilized Multiphasic Personality Questionnaire and Weschlers Adult Intelligence Scale for neuropsychiatric assessment.
Assessed brain structure using 1.5T MRI and hippocampal volumetric studies.

Main Results:

Epileptic patients showed significantly higher anxiety and depression than controls.
Anxiety and depression scores differed significantly between patient groups.
Group 3 (MCD) and Group 4 (IHI) had significantly different anxiety scores, but not depression scores.

Conclusions:

High prevalence of anxiety and depression in intractable epilepsy confirmed.
Anxiety is notably prevalent in cases of incomplete hippocampal inversion (IHI), especially when co-occurring with depression.
Recommends identifying IHI in intractable epilepsy patients for effective anxiety and depression management.