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Updated: Oct 20, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Metabolic emergencies in pregnancy
1St Thomas' Hospital, London, UK naina.mohan@gstt.nhs.uk.
Pregnancy causes metabolic changes, increasing risks of diabetic ketoacidosis, hypoglycemia, and hyponatremia. This review details these conditions, their treatments, and impacts on mothers and newborns.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Endocrinology
Background:
- Physiological changes during pregnancy alter maternal metabolism.
- Increased frequency of diabetic ketoacidosis and hypoglycemia in pre-existing and gestational diabetes.
- Starvation ketoacidosis and peripartum hyponatremia are significant concerns.
Purpose of the Study:
- To review metabolic disturbances in pregnancy.
- To detail diabetic ketoacidosis, hypoglycemia, and hyponatremia.
- To discuss treatment priorities and maternal-neonatal impact.
Main Methods:
- Literature review of metabolic disturbances in pregnancy.
- Synthesis of current knowledge on ketoacidosis and hyponatremia.
- Focus on clinical presentation, management, and outcomes.
Main Results:
- Pregnancy predisposes women to metabolic disturbances like ketoacidosis and hypoglycemia.
- Peripartum hyponatremia is a recognized condition with potential morbidity.
- These conditions require specific management strategies.
Conclusions:
- Understanding and managing these metabolic issues is crucial for maternal and neonatal well-being.
- Prompt diagnosis and treatment are essential to mitigate risks.
- This review provides a comprehensive overview for clinicians.
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