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Related Experiment Video

Updated: Oct 20, 2025

Optimizing Isolation and Purification of Murine Glomerular Mesangial Cells

Optimizing Isolation and Purification of Murine Glomerular Mesangial Cells

Published on: March 7, 2025

The Mesangial cell - the glomerular stromal cell.

Shimrit Avraham¹, Ben Korin¹, Jun-Jae Chung²

¹Department of Research Biology, Genentech, South San Francisco, CA, USA.

Nature Reviews. Nephrology

|September 11, 2021

Summary

Mesenchymal stromal cells (MSCs) are crucial for kidney health and disease. Understanding MSCs offers new insights into mesangial cell function and chronic kidney disease therapies.

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Optimizing Isolation and Purification of Murine Glomerular Mesangial Cells

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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Area of Science:

Nephrology
Cell Biology
Biomedical Science

Background:

Mesangial cells are vital stromal cells for kidney glomerular homeostasis and injury response.
Mesenchymal stromal cells (MSCs) influence tissue architecture, development, vascularization, and cell fate.
MSCs regulate immunity, inflammation, regeneration, and fibrosis through cell crosstalk and matrix remodeling.

Purpose of the Study:

To review current understanding of MSCs.
To discuss how MSC knowledge informs mesangial cell function and disease roles.
To explore potential for new chronic kidney disease therapies.

Main Methods:

Literature review and synthesis of existing research on MSCs and kidney mesangial cells.

Main Results:

Kidney mesangial cells exhibit characteristics of specialized glomerular stromal cells.
MSC functions provide a framework for understanding mesangial cell roles in the kidney.

Conclusions:

Understanding MSCs enhances insights into mesangial cell biology and kidney disease pathogenesis.
New therapeutic strategies for chronic kidney disease may emerge from this understanding.