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Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

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Time coding in rat dorsolateral striatum.

Alessandro Toso¹, Sebastian Reinartz¹, Francesca Pulecchi¹

¹Cognitive Neuroscience, International School for Advanced Studies, Via Bonomea 265, 34136 Trieste, Italy.

|September 11, 2021

Summary

This summary is machine-generated.

The dorsolateral striatum (DLS) encodes temporal information inherently, regardless of perceived duration or task relevance. This neural signal reflects trial progression rather than specific stimulus timing.

Keywords:

delayed discrimination task duration perception freely moving neuronal encoding of stimulus duration rat sensory perception striatum tactile time perception vibration

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Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

The dorsolateral striatum (DLS) is implicated in various cognitive functions, including motor control and habit formation.
Understanding the neural mechanisms of time perception is crucial for deciphering complex cognitive processes.

Purpose of the Study:

To investigate the role of the dorsolateral striatum (DLS) in the neural encoding of time.
To differentiate between the representation of trial time and perceived stimulus duration within the DLS.

Main Methods:

Neuronal activity was recorded in rats performing temporal discrimination tasks involving sequential vibrations.
Bayesian decoding techniques were employed to analyze population neural activity.
Stimulus intensity and trial accuracy were manipulated to assess their impact on temporal encoding.

Main Results:

DLS activity represented the unfolding of the trial across time but did not selectively encode stimulus durations.
Perceived duration, influenced by stimulus intensity, did not alter the decoded time from the DLS.
The DLS encoded stimulus duration even when it was perceptually irrelevant, as seen in intensity discrimination tasks.

Conclusions:

The DLS contains inherent temporal information related to trial progression, independent of perceived stimulus duration.
Neural activity in the DLS reflects a general sense of time passage rather than specific temporal intervals.
These findings suggest a fundamental role for the DLS in processing temporal information that underlies various cognitive functions.