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In vitro effect of trifluoperazine on human lymphocytes
A Suryanarayana1, P Rita, P P Reddy
1Institute of Genetics, Osmania University, Begumpet, Hyderabad, Aandra Pradesh, India.
The Japanese Journal of Experimental Medicine
|October 1, 1987
Abstract:
Trifluoperazine, a phenothiazine group of tranquilizer was studied for its chromosome damaging effect in human lymphocyte cultures. The cells were treated with 10, 15 and 20 micrograms/culture of trifluoperazine for 24, 48 and 72 hours. A high incidence of chromatid breaks and gaps was observed after 48 and 72 hours treatment. The study revealed that the drug acts mostly on the late S and G2 phase of the cell cycle.