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Published on: February 28, 2019
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Outcome for sinonasal malignancies: a population-based survey
Anna Hafström1,2, Johanna Sjövall3,4, Simon S Persson3,4
1Department of ORL, Head & Neck Surgery, Skåne University Hospital, 221 85, Lund, Sweden. anna.hafstrom@skane.se.
Summary
This study analyzed outcomes for sinonasal malignancies (SNM), finding survival rates better than previous reports, especially for specific subtypes. These findings support future clinical trials for SNM treatment.
Area of Science:
- Oncology
- Head and Neck Surgery
- Cancer Research
Background:
- Sinonasal malignancies (SNM) are rare cancers with diverse histopathology.
- Population-based data for SNM are limited, hindering treatment trial development.
Purpose of the Study:
- To assess overall and histology-specific outcomes for SNM patients.
- To provide data for future randomized controlled treatment trials (RCTs).
Main Methods:
- Retrospective, population-based cohort study of SNM patients (2001-2019).
- Analysis of outcomes based on age, gender, site, stage, histopathology, and treatment modalities.
Main Results:
- 226 patients identified; 61% presented with stage IV disease.
- 5- and 10-year overall survival rates were 57% and 35%.
- Age, stage IVB, melanoma, and definitive chemoradiotherapy were independent prognostic factors for mortality.
Conclusions:
- Outcomes for SNM appear improved compared to prior studies, particularly for mucosal melanoma, adenocarcinoma, and undifferentiated carcinoma.
- Results offer a foundation for histology-specific treatment strategies in SNM.
