Related Experiment Video

Updated: Oct 20, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.6K

Mechanisms, time course and predictability of premature ventricular contractions cardiomyopathy-an update on its

C Cojocaru1, D Penela2, Antonio Berruezo3,4

  • 1Clinical Emergency Hospital, Bucharest, Romania.

Heart Failure Reviews
|September 12, 2021
PubMed

Insights

Frequent premature ventricular contractions (PVCs) can cause heart muscle dysfunction. This review synthesizes current knowledge on PVC-induced cardiomyopathy, its reversibility, and associated conditions, aiding clinical practice.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Frequent premature ventricular contractions (PVCs) are linked to left ventricular systolic dysfunction (LVSD).
  • Predictors for cardiomyopathy (CMP) development are known, but precise risk and reversibility after PVC suppression remain unclear.
  • Limited data exists on the time course of CMP development/resolution and associated right ventricular (RV) and atrial myopathies.

Purpose of the Study:

  • To synthesize recent information on PVC-induced cardiomyopathy (CMP).
  • To provide a deeper understanding of this heart failure scenario.
  • To describe mechanisms, time course, and predictors of reverse remodeling after arrhythmia suppression.

Main Methods:

  • Review of recent scientific literature and clinical experiences.
  • Synthesis of information on mechanisms, time course, and predictors of reverse remodeling.
  • Exploration of experimental models and clinical data.

Main Results:

  • The review details the mechanisms and time course of PVC-induced CMP development and resolution.
  • Predictors for reverse remodeling after PVC suppression are described.
  • Associated RV and atrial myopathies are discussed.

Conclusions:

  • Understanding PVC-induced CMP is crucial for tailored patient monitoring and early treatment.
  • The review proposes a new paradigm for multi-level, multi-modality evaluation and potential early intervention.
  • Further research into the precise risk and reversibility of PVC-induced CMP is warranted.

Keywords:
CardiomyopathyCatheter ablationPredictorsPremature ventricular contraction arrhythmiaTime-to-event outcome

More Related Videos

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.4K
Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices09:35

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

10.2K

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.3K
Cardiac Action Potential01:30

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
3.6K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
96
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
79
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
128
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
7.6K