3D Hydrazone-Functionalized Covalent Organic Frameworks as pH-Triggered Rotary Switches

Wenjuan Zhao1, Chengyang Yu1, Jie Zhao2

  • 1State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, 130012, P. R. China.

Summary

Researchers developed novel 3D functionalized covalent organic frameworks (COFs) that act as pH-triggered molecular switches for smart drug delivery. These hydrazone-decorated COFs demonstrate controlled release of cytarabine (Ara-C), improving drug targeting.

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