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Expert consensus on clinical management of metabolic bone disease of prematurity (2021)

Chang Yan-Mei1, Lin Xin-Zhu, Zhang Rong

  • 1Department of Pediatrics, Peking University Third Hospital, Beijing 100191 China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 13, 2021
PubMed

Insights

Metabolic bone disease of prematurity (MBDP) is a bone condition affecting premature infants. This expert consensus provides clinical management guidelines to improve outcomes for affected infants.

Area of Science:

  • Neonatology
  • Pediatric Endocrinology
  • Bone Metabolism

Background:

  • Metabolic bone disease of prematurity (MBDP) is a significant concern in neonatology, characterized by reduced bone mineral content due to calcium and phosphorus imbalances.
  • Clinical management of MBDP in China lacks systematic research and standardization, leading to varied patient outcomes.
  • Understanding and addressing MBDP is crucial for improving the health of premature infants.

Purpose of the Study:

  • To establish an expert consensus on the clinical management of MBDP in China.
  • To provide evidence-based recommendations for practitioners to standardize care.
  • To reduce MBDP incidence and enhance short- and long-term prognoses for affected infants.

Main Methods:

  • Utilized the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.
  • Synthesized findings from relevant domestic (China) and international studies.
  • Developed expert consensus guidelines based on comprehensive literature review and clinical expertise.

Main Results:

  • The consensus provides recommendations covering five key areas: high-risk factors, screening and diagnosis, prevention strategies, treatment protocols, and post-discharge follow-up.
  • Specific guidance is offered to address the current irregularities in MBDP clinical management.
  • The recommendations aim to standardize care and improve the quality of life for premature infants with MBDP.

Conclusions:

  • The developed expert consensus offers a systematic approach to managing MBDP in premature infants.
  • Implementation of these guidelines is expected to reduce MBDP incidence and improve patient prognosis.
  • This consensus serves as a vital resource for healthcare professionals involved in the care of premature neonates.

Keywords:
Bone mineralization and growthExpert consensusMetabolic bone diseaseOsteopeniaPreterm infant

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