Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrian Elter1,2, Jan P Bogen1,3, Jan Habermann1

  • 1Institut für Organische Chemie und Biochemie, TU Darmstadt, Darmstadt, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|September 13, 2021
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid and Efficient Antibody-Drug Conjugate Design Using Mechanistic Bottom-Up Modeling from In Vitro to Human.

Bioconjugate chemistry·2026
Same author

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity.

Frontiers in immunology·2026
Same author

A masking clamp for conditional activation of therapeutic antibodies.

Frontiers in immunology·2025
Same author

Covalent and Site-Specific Immobilization of a Fluorogenic Sensor Protein on Cellulose-Based Paper for Detection of Lactate in Cell Culture Media.

Biosensors·2025
Same author

iBody-mediated tuning of synthetic cytokine receptor activation via rational nanobody interface engineering.

mAbs·2025
Same author

Computational Prediction of Single-Domain Immunoglobulin Aggregation Propensities Facilitates Discovery and Humanization of Recombinant Nanobodies.

Antibodies (Basel, Switzerland)·2025

Chicken antibodies offer a powerful alternative to traditional options. Their unique immune response to human proteins and reduced cross-reactivity make them ideal for immunotherapy and biotechnology.

Area of Science:

  • Immunology
  • Biotechnology
  • Comparative genomics

Context:

  • The evolutionary distance between birds (Aves) and humans provides a unique advantage for antibody production.
  • Mammalian proteins elicit a strong adaptive immune response in chickens.
  • Chicken antibodies exhibit reduced cross-reactivity compared to rodent antibodies in analytical applications.

Purpose:

  • To highlight the advantages of chicken-derived antibodies for therapeutic and biotechnological uses.
  • To explore the potential of avian immune systems in generating specific antibodies.
  • To present chicken antibodies as a viable alternative to conventional antibody sources.

Summary:

  • Immunization of chickens with human proteins results in a robust adaptive immune response.

Related Experiment Videos

  • Chicken antibodies demonstrate lower non-specific binding in assays.
  • Antibody-coding genes from chickens are easily amplified, facilitating their application.

    • Impact:

    • Chicken antibodies present promising applications in immunotherapy.
    • These antibodies offer potential for diverse biotechnological applications.
    • The unique properties of chicken antibodies enhance their utility in research and development.