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Interactive Association Between CYP2C9 rs2860905 Polymorphism and Atrial Fibrillation on Ischemic Stroke in Taiwan

Jui-Wen Peng1, Oswald Ndi Nfor2, Chien-Chang Ho3,4

  • 1Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.

Pharmacogenomics and Personalized Medicine
|September 13, 2021
PubMed

Insights

The GG genotype of the CYP2C9 rs2860905 variant increases ischemic stroke risk in Taiwanese adults, especially when combined with atrial fibrillation. This genetic factor is crucial for understanding stroke in Taiwan.

Area of Science:

  • Cardiovascular Genetics
  • Neurology
  • Pharmacogenomics

Background:

  • Ischemic stroke is a leading cause of disability, with atrial fibrillation as a significant risk factor.
  • Limited evidence exists on the interplay between atrial fibrillation, genetic variants, and ischemic stroke risk.

Purpose of the Study:

  • To investigate the association between the CYP2C9 rs2860905 variant, atrial fibrillation, and ischemic stroke risk in the Taiwan Biobank population.
  • To assess the role of genetic factors in ischemic stroke among Taiwanese adults.

Main Methods:

  • Logistic regression analysis was employed to analyze data from 17,726 participants in the Taiwan Biobank.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated to determine the risk associated with atrial fibrillation and the rs2860905 variant.
  • Genotype-stratified analysis was performed to examine gene-environment interactions.

Main Results:

  • Atrial fibrillation showed a significant positive association with ischemic stroke (OR=3.70; 95% CI, 2.21-6.20).
  • The rs2860905 variant itself was not directly associated with ischemic stroke risk (OR=1.00; 95% CI, 0.82-1.22 for GA/AA vs. GG genotype).
  • Individuals with the GG genotype and atrial fibrillation had a substantially higher risk of ischemic stroke (OR=4.68; 95% CI, 2.70-8.09) compared to those without atrial fibrillation.

Conclusions:

  • The GG genotype of CYP2C9 rs2860905 significantly enhances ischemic stroke risk in Taiwanese adults, particularly when co-occurring with atrial fibrillation.
  • This genotype-specific risk warrants consideration in clinical and research settings for stroke prevention and management in Taiwan.
  • Understanding genetic predispositions like the CYP2C9 rs2860905 variant is vital for personalized medicine approaches to cardiovascular diseases.
Abstract

Keywords:
genetic variationrisk predictionstroke

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