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The Function and related Diseases of Protein Crotonylation

Shuo Wang1, Guanqun Mu1, Bingquan Qiu1

  • 1Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

International Journal of Biological Sciences
|September 13, 2021
PubMed

Insights

Crotonylation, a newly discovered protein modification, plays key roles in gene expression and cell processes. This review details crotonylation mechanisms and its links to diseases like cancer.

Area of Science:

  • Biochemistry and Molecular Biology
  • Epigenetics
  • Post-translational Modifications

Background:

  • Crotonylation is a recently identified acylation modification impacting numerous proteins.
  • It shares enzymes with acetylation and influences vital biological functions.
  • Dysregulated crotonylation is implicated in various diseases, including cancer and depression.

Purpose of the Study:

  • To review the research progress of crotonylation.
  • To discuss the regulatory mechanisms of crotonylation in histone and non-histone proteins.
  • To highlight the role of crotonylation in physiological and pathological conditions.

Main Methods:

  • Literature review and synthesis of existing research on protein crotonylation.
  • Analysis of studies investigating crotonylation mechanisms in different biological processes.
  • Examination of pathological alterations and disease associations of crotonylation.

Main Results:

  • Thousands of crotonylation sites have been identified in proteins.
  • Crotonylation is involved in gene expression, spermatogenesis, and cell cycle regulation.
  • Alterations in crotonylation are linked to diseases such as depression and cancer.

Conclusions:

  • Crotonylation is a significant post-translational modification with broad biological implications.
  • Understanding crotonylation mechanisms is crucial for deciphering its role in health and disease.
  • Further research into crotonylation holds potential for novel therapeutic strategies.
Keywords:
crotonylationdiseasehistone crotonylationnon-histone crotonylation

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