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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Acupuncture Modulation Effect on Pain Processing Patterns in Patients With Migraine Without Aura.

Zilei Tian^1,2, Yaoguang Guo³, Tao Yin^1,2

¹Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Neuroscience

|September 13, 2021

Summary

Migraine patients exhibit abnormal brain connectivity in pain-processing regions. Acupuncture treatment partially restores this connectivity, suggesting it regulates pain perception and processing for headache relief.

Keywords:

acupuncture fMRI functional connectivity migraine without aura pain processing resting-state

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Area of Science:

Neuroscience
Medical Imaging
Pain Research

Background:

Migraine is associated with altered resting-state functional connectivity (FC) in pain processing pathways.
Investigating these FC patterns can reveal pathological mechanisms in migraine.
Understanding how treatments like acupuncture affect brain activity during migraine is crucial.

Purpose of the Study:

To identify abnormal functional connectivity (FC) patterns in patients with migraine without aura (MwoA) compared to healthy controls (HCs).
To evaluate the impact of acupuncture treatment on FC in MwoA patients during the interictal period.
To explore the relationship between altered FC and clinical migraine symptoms.

Main Methods:

Retrospective analysis of resting-state fMRI data from 52 MwoA patients and 60 HCs.
Region of interest (ROI)-to-ROI analysis focusing on pain processing networks.
MwoA patients received 4 weeks of acupuncture treatment; fMRI scans were acquired pre- and post-treatment.

Main Results:

Significantly different FCs were observed between MwoA patients and HCs, particularly involving the cingulate gyrus, insular gyrus, inferior parietal lobule, and superior/middle frontal gyri.
Acupuncture treatment demonstrated partial restoration of these abnormal FCs in MwoA patients.
Subgroup analyses revealed distinct brain activity patterns related to headache intensity and frequency restoration, with correlations between FC and clinical symptoms.

Conclusions:

Migraine is characterized by abnormal functional connectivity in frontal, parietal, and limbic regions, potentially serving as a pathological feature.
Acupuncture effectively relieves migraine symptoms by restoring pain processing functions and modulating pain perception.
These findings highlight the neurobiological underpinnings of migraine and the therapeutic mechanisms of acupuncture.