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Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe

Claire S Martin1, Mark S Cooper2, Rowan S Hardy3,4

  • 1Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

Frontiers in Endocrinology
|September 13, 2021
PubMed

Insights

Tissue-specific metabolism of glucocorticoids (GCs) by 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes critically impacts bone homeostasis. Modulating GC metabolism offers potential therapeutic strategies for bone diseases.

Area of Science:

  • Endocrinology
  • Metabolic Disease Research
  • Bone Biology

Background:

  • Glucocorticoids (GCs) play a vital role in human health and disease.
  • Tissue-specific metabolism of GCs is crucial for their function.
  • 11β-hydroxysteroid dehydrogenase (11β-HSD) enzymes regulate GC activity by interconverting active and inactive forms.

Purpose of the Study:

  • To review the role of endogenous and therapeutic GC metabolism by 11β-HSD enzymes in bone homeostasis.
  • To explore the impact of GC metabolism on bone cell function.
  • To consider future therapeutic strategies targeting GC metabolism for bone diseases.

Main Methods:

  • Literature review focusing on the role of 11β-HSD enzymes in GC metabolism.
  • Analysis of studies investigating GC metabolism in the context of bone homeostasis and cell function.
  • Synthesis of current knowledge and future directions in the field.

Main Results:

  • Localised pre-receptor metabolism of GCs by 11β-HSD enzymes is critical for bone homeostasis.
  • GC metabolism influences both positive and negative actions on bone.
  • Dysregulation of GC metabolism is implicated in various bone diseases.

Conclusions:

  • 11β-HSD enzymes are key regulators of GC action in bone.
  • Targeting GC metabolism presents a promising therapeutic avenue for managing bone diseases.
  • Further research into modulating GC metabolism could lead to novel treatments for metabolic and bone disorders.
Keywords:
11beta-hydroxysteroid dehydrogenasebonechronic inflammationglucocorticoidosteoblastosteoclastosteoporosis

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