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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
259
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

570
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
570
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.1K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

557
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
557
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

419
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
419
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

468
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Related Experiment Video

Updated: Oct 20, 2025

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
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Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

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Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After

Xiong Xia1, Jiangjin Ni1, Shengnan Yin1

  • 1Department of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, China.

Frontiers in Microbiology
|September 13, 2021
PubMed
Summary

Cardiovascular surgery disrupts the gut microbiome, increasing inflammation and impairing gut barrier function. This microbiome disorder is linked to poor patient outcomes, suggesting a role in perioperative care.

Keywords:
cardiovascular diseasesgut barriergut local inflammationgut microbiomeperioperationsystemic inflammatory response

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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Murine Ileocolic Bowel Resection with Primary Anastomosis

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Area of Science:

  • Microbiome research
  • Cardiovascular surgery
  • Inflammatory response

Background:

  • Systemic inflammation post-cardiovascular surgery correlates with poor prognosis.
  • Gut barrier impairment is a known factor in this inflammatory response.

Purpose of the Study:

  • To investigate the association between perioperative gut microbiome alterations and systemic/intestinal inflammatory responses.
  • To examine changes in gut microbiome, intestinal homeostasis, and inflammation markers in cardiovascular patients.

Main Methods:

  • Collected gut microbiome, intestinal homeostasis, and inflammatory markers from cardiovascular patients.
  • Analyzed samples pre-surgery (Pre) and post-surgery (Po1, Po2).
  • Utilized microbiome sequencing and Spearman correlation analysis.

Main Results:

  • Systemic inflammatory response and gut barrier dysfunction significantly increased post-surgery (Po1, Po2).
  • Gut microbiome alpha diversity declined, with a decrease in beneficial anaerobes and an increase in Enterococcus.
  • Microbiome disorder correlated with enhanced systemic inflammation and intestinal dysbiosis.

Conclusions:

  • Gut microbiome alterations are linked to disturbed gut homeostasis and elevated plasma endotoxin post-cardiovascular surgery.
  • These findings suggest the gut microbiome's role in perioperative outcomes.
  • Highlights potential for microbiome-based diagnostic and therapeutic strategies in cardiovascular surgery patients.