Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors

Area of Science:

• Oncology
• Nephrology
• Genitourinary Pathology

Background:

• Xp11.2 translocation renal cell carcinoma (tRCC) is rare, more common in children, and aggressive in adults.
• Limited clinical data and prognostic studies exist for adult Xp11.2 tRCC patients due to its rarity.

Purpose of the Study:

• To investigate clinical characteristics and identify prognostic factors for adult patients with Xp11.2 tRCC.
• To determine independent risk factors for progression-free survival and overall survival in this patient cohort.

Main Methods:

• Retrospective single-center study of 24 adult patients diagnosed with Xp11.2 tRCC.
• Collected clinical presentations, baseline laboratory results, and follow-up data.
• Utilized chi-square, t-tests, and multivariate Cox regression to analyze risk factors for progression and survival.

Main Results:

• Higher C-reactive protein-to-albumin ratio, baseline fibrinogen, and distant metastasis were associated with progression in univariate analysis.
• Higher preoperative fibrinogen and distant metastasis were linked to death.
• Multivariate analysis identified only baseline fibrinogen level as an independent predictor of progression-free survival, and fibrinogen level and distant metastasis for overall survival.

Conclusions:

• Elevated CRP/Alb ratios, fibrinogen, and distant metastasis correlate with poor prognosis in adult Xp11.2 tRCC.
• Baseline fibrinogen is an independent predictor of progression in adult Xp11.2 tRCC.
• Fibrinogen levels and distant metastasis are independent predictors of survival in adult Xp11.2 tRCC.