Spontaneous recovery of immune checkpoint inhibitor-induced thyroiditis with high free T4 level: A case report

Rie Hagiwara1, Daisuke Suzuki1, Shiori Tonezawa1

  • 1Department of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center Saitama Japan.

Clinical Case Reports
|September 13, 2021
PubMed

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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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