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Optical dosimeter for selective retinal therapy based on multi-port fiber-optic interferometry.

Uihan Kim1,2, Minsung Kwon1,2, Gyeongyeon Jung3

  • 1Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

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Selective retinal therapy (SRT) requires precise real-time monitoring. A novel multi-port fiber-based interferometer (MFI) accurately measures energy fluctuations during SRT, correlating with treatment effectiveness and cell death.

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Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Medical Instrumentation

Background:

  • Selective Retinal Therapy (SRT) uses short-pulse lasers for targeted retinal treatment.
  • Precise, real-time monitoring of pulse energy thresholds is crucial for effective SRT, as these vary between patients and disease states.
  • Current methods lack the sensitivity for real-time adjustments during SRT procedures.

Purpose of the Study:

  • To develop and evaluate a Multi-Port Fiber-based Interferometer (MFI) for sensitive, real-time monitoring of Selective Retinal Therapy (SRT).
  • To quantitatively measure localized fluctuations during SRT using phase differences in the MFI.
  • To identify metrics derived from complex-valued information that correlate with SRT outcomes.

Main Methods:

  • Utilized a Multi-Port Fiber-based Interferometer (MFI) to capture complex-valued optical information during SRT.
  • Analyzed phase differences among fiber ports to quantify localized fluctuations.
  • Evaluated various metrics, including complex contour integration, for correlation with pulse energy, acoustic output, and cell death.

Main Results:

  • Complex contour integration demonstrated high sensitivity and strong correlation with pulse energies, acoustic outputs, and cell death.
  • The MFI system achieved high sensitivity (0.92) and specificity (0.88) in detecting treatment effects on excised porcine retinas.
  • Real-time monitoring capabilities were validated against cell viability assays.

Conclusions:

  • The MFI system provides a highly sensitive and accurate method for real-time monitoring of Selective Retinal Therapy (SRT).
  • Complex contour integration is a key metric for assessing SRT effectiveness and predicting outcomes.
  • This technology holds promise for optimizing SRT procedures and improving patient treatment outcomes.