Cardiovascular System Involvement in Cystic Fibrosis
Prutha H Shah1, Jun Hee Lee2, Dhairya J Salvi2
1Internal Medicine, Pediatrics, California Institute of Behavioral Neurosciences & Psychology (CIBNP), Fairfield, USA.
Cureus
|September 13, 2021
Summary
Cardiovascular complications are a growing concern in cystic fibrosis (CF). Early detection of heart dysfunction in CF patients can significantly improve survival rates and quality of life.
Area of Science:
- Cardiology
- Pulmonology
- Genetics
Background:
- Cystic fibrosis (CF) primarily impacts respiratory and gastrointestinal systems.
- Improved life expectancy in CF presents new challenges, notably cardiovascular pathology.
- Cardiovascular complications are an emerging concern in the CF population.
Purpose of the Study:
- To elucidate mechanisms causing cardiovascular complications in CF patients.
- To guide development of treatments improving survival and quality of life for CF patients.
- To understand the direct and indirect cardiovascular involvement in CF.
Main Methods:
- Systematic review of 258 articles from PubMed and Google Scholar.
- Selection of 12 high-quality articles based on PRISMA guidelines and quality assessment.
- Comprehensive review of theories linking CF to cardiovascular issues.
Main Results:
- Multiple factors contribute to cardiovascular pathology in CF, including lung disease, hypoxia, inflammation, and genetic factors.
- Right ventricular hypertrophy, ventricular interdependence, and myocardial fibrosis are key concerns.
- Early detection of cardiovascular dysfunction is crucial for improved patient outcomes.
Conclusions:
- Understanding CF-related cardiovascular mechanisms is vital for effective treatment.
- Early screening for cardiovascular dysfunction can enhance survival rates in CF patients.
- This review can inform future research on optimal screening modalities for CF cardiovascular health.
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