Ki-67 and Its Relation With Complete Pathological Response in Patients With Breast Cancer

Area of Science:

• Oncology
• Cell Biology

Background:

• Ki-67 is a nuclear antigen indicating cell proliferation.
• Elevated Ki-67 levels are linked to better chemotherapy response and survival in breast cancer.

Purpose of the Study:

• To determine the frequency of high Ki-67 levels in breast cancer patients.
• To correlate Ki-67 levels with complete pathological response after neoadjuvant chemotherapy.

Main Methods:

• Descriptive case series with correlational design.
• Analysis of 80 locally advanced breast cancer patients undergoing neoadjuvant chemotherapy.
• Ki-67 levels assessed via trucut biopsy, correlated with post-operative pathological response.

Main Results:

• 27% of patients had high Ki-67 levels.
• High Ki-67 correlated with a 63% complete pathological response rate.
• Low Ki-67 correlated with only a 17% complete pathological response rate (p=0.00018).

Conclusions:

• High Ki-67 values in breast cancer predict a significantly higher likelihood of complete pathological response to chemotherapy.
• Ki-67 can be integrated into initial assessments to predict chemotherapy effectiveness and patient response.