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Updated: Oct 20, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

The Macklin Effect in COVID-19.

Noreena Iqbal¹, Ayesha Malik², Manahil Chaudhry²

¹Internal Medicine, Milton Keynes University Trust Hospital, Milton Keynes, GBR.

|September 13, 2021

Summary

This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organs, not just the lungs. Spontaneous pneumomediastinum (SP) is a rare but documented complication in patients with coronavirus disease 2019 (COVID-19).

Keywords:

covid complications covid-19 macklin effect pneumomediastinum pneumothorax

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Area of Science:

Pulmonology
Infectious Diseases
Critical Care Medicine

Background:

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has demonstrated multi-organ involvement beyond initial respiratory system focus.
While numerous complications associated with SARS-CoV-2 infection are documented, rare conditions continue to emerge.

Observation:

Spontaneous pneumomediastinum (SP), characterized by air in the mediastinum without a clear precipitating event, has been observed in some COVID-19 patients.
This observation suggests a potential link between SARS-CoV-2 infection and the development of SP, even in the absence of typical risk factors.

Findings:

The occurrence of spontaneous pneumomediastinum (SP) in COVID-19 patients represents an uncommon but significant clinical finding.
This complication highlights the diverse and sometimes unexpected ways SARS-CoV-2 can impact patient physiology.

Implications:

Understanding the association between SARS-CoV-2 and SP is crucial for clinicians managing COVID-19 patients, enabling timely diagnosis and appropriate treatment.
Further research into the pathophysiological mechanisms linking SARS-CoV-2 infection to SP may reveal novel insights into viral pathogenesis and patient management strategies.