Related Experiment Video
Updated: Oct 20, 2025

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
Primary Cilia-Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma
Minghao Li1, Jiaxun Zhang1, Haonan Zhou2
1Xiangya School of Medicine, Central South University, Changsha, China.
Abstract:
As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the development of the central nervous system. The presence or absence of this special organelle may regulate the central nervous system tumorigenesis (e.g., glioblastoma) and several degenerative diseases. Additionally, the development of primary cilia can be regulated by several pathways. Conversely, primary cilia are able to regulate a few signaling transduction pathways. Therefore, development of the central nervous system tumors in conjunction with abnormal cilia can be regulated by up- or downregulation of the pathways related to cilia and ciliogenesis. Here, we review some pathways related to ciliogenesis and tumorigenesis, aiming to provide a potential target for developing new therapies at genetic and molecular levels.
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