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Updated: Oct 20, 2025
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Published on: June 7, 2011
Advances in Nanomaterials for Injured Heart Repair
Jiacheng Guo1,2, Zhenzhen Yang3, Xu Wang4
1Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Insights
Nanomaterials offer a promising approach to treat atherosclerotic cardiovascular disease (ASCVD) by enhancing therapeutic efficacy and safety. This review explores nanomaterial mechanisms, delivery, and future potential in cardiac regeneration for ASCVD.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Nanotechnology
Background:
- Atherosclerotic cardiovascular disease (ASCVD) is a major global cause of mortality.
- Limited myocardial regenerative capacity post-infarction necessitates novel therapeutic strategies.
- Current ASCVD treatments face challenges in safety and efficacy.
Purpose of the Study:
- To review the pathophysiological mechanisms of ASCVD.
- To explore the multifunctional mechanisms of nanomaterial (NM)-based therapies for ASCVD.
- To examine technological improvements in NM delivery and clinical applications for cardiac regeneration.
Main Methods:
- Comprehensive literature review of nanomaterials in ASCVD treatment.
- Analysis of NM mechanisms including antioxidative, anti-inflammatory, and anti-apoptotic effects.
- Evaluation of NM delivery systems and clinical translation.
Main Results:
- Nanomaterials demonstrate potential to improve safety and efficacy in ASCVD therapy.
- NMs offer antioxidative, anti-inflammatory, and anti-apoptotic benefits.
- Advancements in NM delivery enhance therapeutic potential for cardiac regeneration.
Conclusions:
- Nanomaterials represent a significant advancement in ASCVD treatment and cardiac regeneration.
- Further research and clinical translation are needed to overcome challenges.
- Nanotechnology holds promise for future cardiovascular therapies.
Abstract:
Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes of mortality worldwide. Because of the limited regenerative capacity of adult myocardium to compensate for the loss of heart tissue after ischemic infarction, scientists have been exploring the possible mechanisms involved in the pathological process of ASCVD and searching for alternative means to regenerate infarcted cardiac tissue. Although numerous studies have pursued innovative solutions for reversing the pathological process of ASCVD and improving the effectiveness of delivering therapeutics, the translation of those advances into downstream clinical applications remains unsatisfactory because of poor safety and low efficacy. Recently, nanomaterials (NMs) have emerged as a promising new strategy to strengthen both the efficacy and safety of ASCVD therapy. Thus, a comprehensive review of NMs used in ASCVD treatment will be useful. This paper presents an overview of the pathophysiological mechanisms of ASCVD and the multifunctional mechanisms of NM-based therapy, including antioxidative, anti-inflammation and antiapoptosis mechanisms. The technological improvements of NM delivery are summarized and the clinical transformations concerning the use of NMs to treat ASCVD are examined. Finally, this paper discusses the challenges and future perspectives of NMs in cardiac regeneration to provide insightful information for health professionals on the latest advancements in nanotechnologies for ASCVD treatment.
