Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

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Updated: Oct 20, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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Lidong Wang1, Xiaodan Sun2, Jingni He1

  • 1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Cell and Developmental Biology
|September 13, 2021
PubMed

Insights

The Deltex (DTX) protein family, crucial ubiquitin E3 ligases, impacts protein stability and cell functions. This review summarizes DTX protein research, highlighting their roles in disease and potential therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Ubiquitination is a key posttranslational modification regulating protein stability and function.
  • Ubiquitin E3 ligases, like the human Deltex (DTX) protein family, dictate substrate specificity in ubiquitination.
  • The DTX family (DTX1-4, DTX3L) plays significant roles in cellular processes and disease.

Purpose of the Study:

  • To review recent advancements in understanding the DTX protein family.
  • To consolidate knowledge on the structural features, biological functions, and mechanisms of DTX proteins.
  • To identify future research directions and therapeutic strategies related to DTX proteins.

Main Methods:

  • Literature review of recent research on DTX family proteins.
  • Synthesis of data on structural characteristics and biological functions.
  • Analysis of DTX protein involvement in physiological and pathological processes.

Main Results:

  • DTX proteins are involved in cell signaling, growth, differentiation, and apoptosis.
  • The DTX family is implicated in the development of various tumors.
  • Despite extensive study, detailed structural and mechanistic data for DTX proteins remain limited.

Conclusions:

  • The DTX protein family exhibits diverse functions and is critical in cellular regulation and disease.
  • Further research is needed to elucidate the structural and mechanistic aspects of DTX proteins.
  • Understanding DTX proteins offers potential for novel diagnostic and therapeutic approaches in diseases like cancer.
Keywords:
Deltex family proteinspost-translational modificationprotein homeostasisubiquitin E3 ligaseubiquitin codeubiquitination

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