Related Experiment Video

Updated: Oct 20, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.5K

Exosomes and Atherogenesis

Bingbing Lin1, Juan Yang1, Yuwei Song1

  • 1Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.

Frontiers in Cardiovascular Medicine
|September 13, 2021
PubMed

Insights

Atherosclerosis, a root cause of heart attack and stroke, involves various cells. Exosomes, tiny cell messengers, are key to understanding and potentially treating this disease.

Area of Science:

  • Cardiovascular Research
  • Cell Biology
  • Nanomedicine

Background:

  • Atherosclerosis underlies major global mortality causes like myocardial infarction and ischemic stroke.
  • Pathogenesis involves endothelial dysfunction, immune cell infiltration, and foam cell accumulation, leading to plaque formation.
  • Key cellular players include endothelial cells, smooth muscle cells, macrophages, lymphocytes, foam cells, and platelets.

Purpose of the Study:

  • To review the pathophysiological roles of exosomes derived from atherosclerosis-associated cells.
  • To explore the potential of exosomes in clinical diagnosis and treatment strategies for atherosclerosis.

Main Methods:

  • Literature review focusing on exosome biology in atherosclerosis.
  • Analysis of exosome cargo (proteins, lipids, nucleic acids) and their intercellular communication functions.
  • Examination of exosome involvement in cellular processes relevant to atherogenesis.

Main Results:

  • Exosomes act as critical intercellular messengers in atherosclerosis.
  • Different cell-derived exosomes influence various stages of atherosclerotic plaque development.
  • Exosomes carry specific molecular signals that modulate target cell behavior.

Conclusions:

  • Exosomes are significant mediators in the pathogenesis of atherosclerosis.
  • Understanding exosome function offers novel avenues for diagnostic and therapeutic interventions.
  • Targeting exosome-mediated communication presents a promising strategy for managing atherosclerosis.

Keywords:
atherosclerosisexosomeimmunocyteinflammationvascular injury

More Related Videos

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.2K
Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media10:45

Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media

Published on: June 14, 2013

32.0K

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.0K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
185
Inflammation01:38

Inflammation

Overview
56.2K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
68
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
767
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
94