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A Murine Model of Vertical Sleeve Gastrectomy
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Early Changes in Immune Cell Count, Metabolism, and Function Following Sleeve Gastrectomy: A Prospective Human Study
Tammy Lo1, Renuka S Haridas1, Eleanor J M Rudge1
1Laboratory for Surgical and Metabolic Research, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
The Journal of Clinical Endocrinology and Metabolism
|September 13, 2021
Summary
Laparoscopic sleeve gastrectomy (LSG) significantly alters immune cell metabolism and blood biomarkers within 3 months. This bariatric surgery impacts inflammatory and metabolic pathways, offering insights into obesity treatment effects.
Area of Science:
- Bariatric surgery
- Immunometabolism
- Obesity research
Background:
- Laparoscopic sleeve gastrectomy (LSG) is a primary bariatric procedure for obesity.
- LSG promotes weight loss and improves comorbidities but its effects on immune function and metabolism are not fully understood.
Purpose of the Study:
- To investigate longitudinal changes in blood biomarkers, leukocyte profiles, and gene expression post-LSG.
- To characterize the impact of LSG on immune cell composition and function.
Main Methods:
- Prospective study of 23 patients undergoing LSG.
- Collected data on weight, comorbidities, blood biomarkers, and leukocyte subsets over 1 year.
- Performed RNA sequencing on whole blood samples at baseline and 3 months.
Main Results:
- LSG resulted in 18.1% body weight loss at 3 months, with improved HbA1c in diabetic patients.
- Observed improvements in inflammatory and hormonal biomarkers, and a reduced neutrophil-lymphocyte ratio.
- Gene expression analysis revealed LSG-induced changes in inflammatory and energy metabolism pathways.
Conclusions:
- LSG significantly alters immune cell metabolism and blood biomarkers by 3 months post-surgery.
- Further research is needed to understand the immunometabolic consequences of bariatric surgery.
