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Medication use and microscopic colitis.

Robert S Sandler1,2, Temitope O Keku1,2, John T Woosley3

  • 1Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA.

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This study found no link between common medications and microscopic colitis. However, patients with microscopic colitis experienced more diarrhea after cholecystectomy, suggesting a potential role for bile in the condition.

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pathology

Background:

  • Microscopic colitis is a growing cause of watery diarrhea.
  • Previous studies suggested links between certain medications and microscopic colitis.

Purpose of the Study:

  • To investigate the association between previously implicated medications and microscopic colitis.
  • To explore potential risk factors for microscopic colitis.

Main Methods:

  • A case-control study involving patients undergoing colonoscopy for diarrhea.
  • Exclusion criteria included inflammatory bowel disease and infectious diarrhea.
  • Cases were classified based on colon biopsy review.

Main Results:

  • No association was found between proton pump inhibitors or NSAIDs and microscopic colitis.
  • Cholecystectomy was less common in microscopic colitis cases.
  • Microscopic colitis cases reported more frequent bowel movements post-cholecystectomy.

Conclusions:

  • Previously implicated medications were not associated with microscopic colitis in this cohort.
  • Increased diarrhea post-cholecystectomy suggests a potential role for bile in microscopic colitis.
  • Careful selection of controls is vital for identifying microscopic colitis risk factors.