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Published on: April 13, 2015
Association between coronary dominance pattern and left ventricular mass index: Is there a gender disparity?
Mehmet Eyuboglu1, Fuat Bice1, Abdullah Emre Bektas1
1Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
Insights
Co-dominance coronary patterns are linked to higher left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH). This pattern is an independent predictor of LVH in women, aiding cardiovascular risk stratification.
Area of Science:
- Cardiology
- Vascular Biology
- Cardiac Imaging
Background:
- Left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) predict cardiovascular events.
- The relationship between coronary circulation patterns and LVMI is not well understood.
Purpose of the Study:
- To investigate the association between coronary dominance patterns and LVMI.
- To determine the impact of coronary dominance on the development of LVH.
Main Methods:
- 367 patients without known cardiovascular disease underwent coronary angiography.
- Patients were categorized by coronary dominance: right (RD), co-dominance (CD), and left (LD).
- Echocardiographic LVMI and LVH prevalence were compared across groups.
Main Results:
- Co-dominance (CD) pattern was associated with significantly higher LVMI compared to RD and LD patterns.
- The CD pattern was more prevalent in patients with LVH.
- CD pattern independently predicted LVH in women, but not in men.
Conclusions:
- Coronary dominance patterns influence LVMI and LVH.
- Coronary dominance may enhance cardiovascular risk stratification, particularly in female patients.
Background:
Increased left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) are independent predictors of adverse cardiovascular events. However, little is known regarding the association between coronary circulation and LVMI. We aimed to investigate the association between coronary dominance and LVMI, and to demonstrate the impact of coronary dominance pattern on the emergence of LVH.
Methods:
In total, 367 consecutive patients without known cardiovascular disease and significant obstructive coronary artery disease who underwent diagnostic coronary angiography were prospectively included in the study. Patients were divided into three groups according to coronary dominance pattern. Patients with right dominance (RD), co-dominance (CD) and left dominance (LD) patterns were compared regarding echocardiographically detected LVMI. Additionally, the association between coronary dominance pattern and LVH was investigated.
Results:
The frequency of RD, CD and LD patterns was 70.3%, 19.1% and 10.6%, respectively. LVMI was significantly higher in patients with CD pattern compared with those with RD and LD patterns (P < .001, for both comparisons). LVH was present in 71 (19.3%) patients. Importantly, the CD pattern was more frequent in patients with LVH compared with those without LVH (P < .001). No significant difference was found between women and men regarding the type of coronary dominance pattern. However, while the presence of CD pattern was found to be an independent predictor of LVH in women (OR:1.221, 95%CI:1.048-1.872, P < .001), no association was observed between coronary dominance pattern and LVH in men.
Conclusions:
Coronary dominance pattern may significantly affect the LVMI, and it may be useful in the further risk stratification of female patients.
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