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HIV-HCV Coinfection: Prevalence and Treatment Outcomes in Malaysia

Ali Akhtar1, Samreen Fatima2, Hamid Saeed2

  • 1Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, George Town, Malaysia.

Intervirology
|September 13, 2021
PubMed

Insights

Hepatitis C virus (HCV) coinfection is prevalent in HIV-positive individuals, particularly males. Intravenous drug use and gender impact treatment outcomes for coinfected patients.

Area of Science:

  • Infectious Diseases
  • Virology
  • Public Health

Background:

  • Global prevalence of Hepatitis C virus (HCV) infections and Human Immunodeficiency Virus (HIV) coinfections.
  • Significant burden of HIV-HCV coinfection worldwide, affecting millions.
  • Need to understand HCV prevalence in HIV-positive populations.

Purpose of the Study:

  • Determine HCV prevalence among HIV-positive individuals.
  • Identify predictors of treatment outcomes in HIV-HCV coinfected patients.

Main Methods:

  • Retrospective, cross-sectional study design.
  • Data collected from 2007-2012 at Hospital Palau Pinang, Malaysia.
  • Statistical analysis using SPSS version 20.0.

Main Results:

  • Overall HCV prevalence of 16.1% in 708 HIV-infected patients.
  • Higher prevalence in males (17.2%) versus females (1.1%).
  • Significant predictors for outcomes: gender (OR=2.015) and intravenous drug use (OR=2.376).

Conclusions:

  • HCV infection impacts CD4 cell recovery in patients on HAART.
  • Recommend screening for HCV in HIV patients who are smokers and intravenous drug users prior to HAART initiation.
Abstract

Keywords:
CoinfectionHepatitis C virusHuman immunodeficiency virusOutcomesPrevalence

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