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Updated: Oct 20, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
Microbiota and the irritable bowel syndrome
Cristina M Sabo1, Dan L Dumitrascu2
1Second Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania - Marica.Cristina@umfcluj.ro.
The gut microbiota, crucial for health, shows altered composition in Irritable Bowel Syndrome (IBS) patients. Understanding these gut-brain-microbiota axis changes is key to IBS pathophysiology.
Area of Science:
- Microbiology
- Gastroenterology
- Human Health
Background:
- The human gut harbors over 10^13 microorganisms, influencing health.
- Gut microbiota composition varies individually and with lifestyle factors.
- Irritable Bowel Syndrome (IBS), a common gut-brain interaction disorder, causes pain and altered bowel habits.
Purpose of the Study:
- To review the role of gut microbiota in IBS pathophysiology.
- To highlight alterations in the gut-brain-microbiota axis in IBS.
Main Methods:
- Literature review on gut microbiota composition in IBS.
- Analysis of microbial profiles in IBS subtypes (IBS-D, IBS-M).
Main Results:
- IBS patients exhibit increased Enterobacteriaceae, Ruminococcus, Clostridium, and Dorea species.
- A decrease in Lactobacillus, Bifidobacterium, and Faecalibacterium species is observed in IBS.
- Microbial profiles show similarities between IBS-D and IBS-M.
Conclusions:
- Gut microbiota perturbations are implicated in IBS development.
- The brain-gut-microbiota axis is a potential factor in IBS pathophysiology.
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