Related Experiment Video
Updated: Oct 20, 2025
06:55
Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
Published on: February 14, 2022
1.8K
Single-lobe transplantation with contralateral pneumonectomy: Long-term survival
Masaki Ikeda1, Hideki Motoyama2, Makoto Sonobe3
1Department of Thoracic Surgery, Graduate School of Medicine, 38049Kyoto University, Japan.
Asian Cardiovascular & Thoracic Annals
|September 13, 2021
Summary
Long-term survival is possible after living-donor lobar lung transplantation with contralateral pneumonectomy. This procedure offers a viable option for patients with pulmonary graft-versus-host disease, enabling daily life activities.
Area of Science:
- Medicine
- Pulmonology
- Transplantation
Background:
- Pulmonary graft-versus-host disease (GVHD) is a severe complication following hematopoietic stem cell transplantation.
- Lung transplantation is a potential treatment option for severe pulmonary GVHD.
- Living-donor lobar lung transplantation (LDLLT) offers an alternative when deceased donors are unavailable.
Observation:
- Two pediatric and adult female patients with pulmonary GVHD underwent LDLLT.
- One patient required simultaneous contralateral pneumonectomy due to an oversized graft.
- The second patient underwent contralateral pneumonectomy 7 years post-transplant due to native lung pneumonia.
Findings:
- Both patients achieved long-term survival, exceeding 11 years post-transplant.
- Despite physical limitations, both patients could perform daily life activities.
- LDLLT combined with pneumonectomy demonstrated successful long-term outcomes in these cases.
Implications:
- This approach may be a feasible strategy for managing complex pulmonary GVHD cases.
- Living-donor lung transplantation can be a life-saving option for patients with limited alternatives.
- Further research is warranted to evaluate the long-term efficacy and safety of this combined procedure.
