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A fungal antigenic driver for Löfgren's syndrome sarcoidosis
Clarice X Lim1, Thomas Weichhart1
1Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria.
Abstract:
Löfgren's syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4+ T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren's syndrome patients in an HLA-DR3-restricted manner. An increased serum IgG antibody response to the full-length protein was also observed in those patients, indicating that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis.
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Fungal Group Zygomycota
Fungal Phylum Microsporidia