Rab35 controls formation of luminal projections required for bile canalicular morphogenesis
Claudiu Andrei Cozmescu1,2, Paul Gissen1,2
1National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
Abstract:
Hepatocytes display a unique biaxial polarity with shared apical luminal connections between adjacent hepatocytes that merge into a network of bile canaliculi. Belicova et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202103003) discovered that hepatocyte apical membranes generate Rab35-dependent extensions that traverse the lumen and are essential for bile canalicular formation and maintenance.
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