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Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
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Immediate breast reconstruction is oncologically safe for node-positive patients: Comparison using propensity score
Goshi Oda1, Tsuyoshi Nakagawa1, Noriko Uemura2
1Department of Specialized Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Medicine
|September 13, 2021
Summary
Immediate breast reconstruction (IBR) is safe for lymph node-positive breast cancer patients. Oncological outcomes, including recurrence-free survival, showed no significant differences compared to non-IBR patients after propensity score matching.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- The oncological safety of immediate breast reconstruction (IBR) in lymph node-positive breast cancer patients remains uncertain.
- Existing studies often lack specific analysis for node-positive cohorts, necessitating further investigation.
Purpose of the Study:
- To evaluate the oncological safety of IBR in patients with axillary lymph node metastases.
- To compare recurrence rates between immediate breast reconstruction and non-reconstruction groups in node-positive breast cancer patients.
Main Methods:
- A retrospective study involving 232 breast cancer patients with axillary lymph node metastases.
- Comparison of two groups: non-IBR (mastectomy) and IBR (tissue expander or flap transfer).
- Propensity score matching was utilized to control for confounding factors like age, tumor stage, and receptor status.
Main Results:
- No significant difference in 5-year locoregional recurrence-free survival (LRRFS) between non-IBR (78.9%) and IBR (85.1%) groups.
- No significant difference in 5-year recurrence-free survival (RFS) between non-IBR (75.6%) and IBR (78.8%) groups.
- Estrogen receptor status and high nuclear grade were identified as significant prognostic factors for RFS, while IBR was not.
Conclusions:
- Immediate breast reconstruction (IBR) demonstrates oncological safety in lymph node-positive breast cancer patients.
- This study provides evidence supporting IBR as a viable option for selected node-positive breast cancer patients.
- Further research with propensity score matching in node-positive cohorts confirms the safety of IBR.
