Ultra pH-sensitive nanocarrier based on Fe₂O₃/chitosan/montmorillonite for quercetin delivery

Harmful side effects of the chemotherapeutic agent have been investigated in many recent studies. Since Fe₂O₃ nanoparticles have proper porosity, they are capable for loading noticeable amount of drugs and controlled release. We developed Fe₂O₃/chitosan/montmorillonite nanocomposite. Quercetin (QC) nanoparticles, which have fewer side effects than chemical anti-tumor drugs, were encapsulated in the synthesized nanocarrier and were characterized by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), vibrating sample magnetometer (VSM), dynamic light scattering (DLS), and zeta potential. For quercetin, the encapsulation efficiency and the loading efficiency of the drug in Fe₂O₃-CS-MMT@QC were found to be about 94% and 57%, respectively. The release profile of QC in different mediums indicated pH-dependency and controlled release of the nanocomposite, adhering to The Weibull kinetic model. Biocompatibility of the Fe₂O₃/CS/MMT nanoparticles against the MCF-7 cells was shown by MTT assay and confirmed by flow cytometry. These data demonstrate that the designed Fe₂O₃-CS-MMT@QC would have potential drug delivery to treat cancer cells.