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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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Published on: June 26, 2020

[Severe alcoholic hepatitis-associated infection].

X W Wu¹, Z X Huang¹

¹Department of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology

|September 13, 2021

Summary

Severe alcoholic hepatitis patients face high infection risks, which impact treatment outcomes. Early diagnosis and broad-spectrum antibiotics are crucial for managing these serious bacterial and fungal infections, especially with rising antimicrobial resistance.

Keywords:

Alcoholic hepatitis Bacteria Fungus Infection Therapy

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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

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Published on: May 25, 2017

Area of Science:

Hepatology
Infectious Diseases
Pharmacology

Background:

Severe alcoholic hepatitis (SAH) patients are highly susceptible to concurrent infections.
Infections significantly impact glucocorticoid response and overall disease prognosis in SAH.
Glucocorticoids, while used in SAH treatment, can increase the risk of serious bacterial and fungal infections.

Purpose of the Study:

To highlight the critical role of concurrent infections in SAH.
To emphasize the impact of infections on glucocorticoid efficacy and patient outcomes.
To underscore the importance of early diagnosis and prompt anti-infective therapy in SAH.

Main Methods:

Review of literature on infections in severe alcoholic hepatitis.
Analysis of the impact of infections on treatment response and prognosis.
Discussion of current anti-infective strategies for SAH.

Main Results:

Gram-negative bacterial infections are the predominant type in SAH.
Invasive fungal infections are a significant concern in this patient population.
Concurrent infections negatively affect glucocorticoid response and worsen prognosis.

Conclusions:

Early diagnosis and empiric anti-infective therapy are vital for managing infections in SAH.
Anti-infective strategies must consider coverage for multidrug-resistant bacteria, especially in high-risk patients.
Prompt and appropriate management of infections is essential for improving outcomes in severe alcoholic hepatitis.