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Updated: Oct 20, 2025

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Sensory materials for microfluidic paper based analytical devices - A review.

Bhavadharini Selvakumar1, Arunkumar Kathiravan1

  • 1Department of Chemistry, Vel Tech Rangarajan Dr Sagunthala R & D Institute of Science and Technology, Avadi, Chennai, 600 062, Tamil Nadu, India.

Talanta
|September 14, 2021
PubMed
Summary

Microfluidic paper-based analytical devices (μPADs) offer low-cost, portable diagnostics. This review details colorimetric and fluorimetric probes for μPADs, enhancing their sensing capabilities and applications.

Keywords:
COVID19ColorimetricFluorimetricNanomaterialsSensorsμPADsμTADs

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Microfluidic paper-based analytical devices (μPADs) are increasingly utilized for diagnostics due to their affordability, ease of fabrication, and portability.
  • These devices leverage passive analyte transport for applications in diagnostics, food safety, environmental monitoring, and electrochemical sensing.
  • Colorimetric and fluorimetric sensors are particularly effective in μPADs for analyte detection.

Purpose of the Study:

  • To systematically review and summarize colorimetric and fluorimetric probes employed in μPADs.
  • To elucidate the structure-activity relationships of various probes used as signaling units in μPADs.
  • To provide insights into probe mechanisms and guide the development of advanced μPADs.

Main Methods:

  • Comprehensive literature review of colorimetric and fluorimetric probes for μPAD applications.
  • Analysis of probe structures, including nanomaterials, nanozymes, polymers, and organic molecules.
  • Evaluation of structure-activity relationships concerning sensing performance and limit of detection.

Main Results:

  • Detailed discussion on the structure-function correlations of diverse chemo- and bio-probes within μPADs.
  • Assessment of sensing capabilities and detection limits for various probe types.
  • Identification of key probe characteristics that enhance μPAD efficiency.

Conclusions:

  • Understanding probe structure-activity relationships is crucial for optimizing μPAD performance.
  • This review facilitates better comprehension of sensing mechanisms and promotes advancements in μPAD technology.
  • Findings support the development of μPADs for critical applications, including COVID-19 diagnostics.