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Related Experiment Videos

Regional time-based functional imaging of hepatocyte function.

M L Freeman1, I Reznikov, W E Barnes

  • 1Nuclear Medicine Services, USVA Hines Hospital, Hines, Illinois 60141.

American Journal of Physiologic Imaging
|January 1, 1987
PubMed
Summary
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Functional imaging using Tc-99m disofenin reveals uptake patterns in liver disease. Healthy livers show homogeneous uptake, while hepatitis and cirrhosis patients exhibit increasingly heterogeneous patterns, aiding in parenchymal disruption analysis.

Area of Science:

  • Nuclear Medicine
  • Hepatology
  • Medical Imaging

Background:

  • Hepatocyte function is crucial for liver health.
  • Assessing parenchymal disruption in liver disease is clinically significant.
  • Tc-99m disofenin is a radiotracer used in liver imaging.

Purpose of the Study:

  • To analyze hepatocyte function using Tc-99m disofenin functional imaging.
  • To investigate the relationship between liver disease and hepatic uptake patterns.
  • To evaluate functional imaging as a tool for quantifying liver parenchymal disruption.

Main Methods:

  • Administered 5 mCi of Tc-99m disofenin to 19 patients.
  • Generated functional images to visualize regional hepatic uptake rates.
  • Graded functional images based on the homogeneity of tracer accumulation.

Related Experiment Videos

  • Analyzed uptake kinetics in normal subjects and patients with hepatitis, cirrhosis, and acute cholecystitis.

    • Main Results:

    • Uptake kinetics were significantly more homogeneous in normal subjects.
    • Heterogeneity of uptake increased progressively in patients with hepatitis and cirrhosis.
    • Functional imaging demonstrated distinct patterns correlating with liver disease severity.

    Conclusions:

    • Functional imaging with Tc-99m disofenin can quantitatively assess hepatocyte function.
    • The degree of heterogeneity in hepatic uptake correlates with parenchymal disruption in liver disease.
    • This technique shows promise as a tool for the analysis of liver disease.