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Related Experiment Videos

Behavioral trait associated with conditioned immunity.

R M Gorczynski1, M Kennedy

  • 1Department of Immunology, University of Toronto, c/o Mt. Sinai Research Institute, Ontario, Canada.

Brain, Behavior, and Immunity
|March 1, 1987
PubMed
Summary
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Mice bred for high open-field activity showed easier conditioned immunosuppression, suggesting a link between maternal behavior and immune responses. This highlights how early life experiences can influence adult immune conditioning.

Area of Science:

  • Behavioral Neuroscience
  • Immunology
  • Genetics

Background:

  • Inbred mouse strains are valuable models for studying behavioral and physiological traits.
  • Activity levels in rodents can be selectively bred over generations.
  • Conditioned immunosuppression is a model for psychoneuroimmunology research.

Purpose of the Study:

  • To investigate the relationship between selective breeding for open-field activity and the ease of demonstrating conditioned immunosuppression.
  • To determine if activity level influences immune conditioning independently of taste aversion learning.
  • To explore the role of maternal factors in immune conditioning.

Main Methods:

  • Selective breeding of mice for high and low open-field activity over nine generations.

Related Experiment Videos

  • Reciprocal skin grafts to monitor genetic drift.
  • Cyclophosphamide:saccharin conditioning paradigm to assess conditioned immunosuppression.
  • Taste aversion conditioning to assess general conditionability.
  • Cross-fostering design to evaluate maternal effects.

    • Main Results:

    • Mice selectively bred for high open-field activity exhibited enhanced susceptibility to conditioned immunosuppression.
    • No significant differences in conditionability were observed between high and low activity groups using taste aversion.
    • Cross-fostering indicated that maternal characteristics associated with open-field activity influenced immune conditioning in adult offspring.

    Conclusions:

    • Open-field activity level, influenced by selective breeding, is associated with the efficacy of conditioned immunosuppression.
    • Maternal factors, potentially linked to activity levels, play a role in modulating immune conditioning in adult mice.
    • These findings suggest a complex interplay between behavior, genetics, and the immune system, potentially mediated by early life environment.